top of page

L-Arginine vs L-Citrulline Malate

L-Arginine and L-Citrulline Malate are amino acids that play important roles in the production of nitric oxide, a molecule involved in vasodilation (widening of blood vessels). The vasodilatory effect can enhance blood flow, which is of interest in various contexts, including sports performance and cardiovascular health. Let's compare L-Arginine and L-Citrulline Malate:


Amino Acid Role: L-Arginine is a conditionally essential amino acid, meaning the body can produce it, but supplementation may be necessary under certain conditions.

Nitric Oxide Production: L-Arginine is a precursor to nitric oxide (NO). When L-Arginine is converted to NO in the body, it leads to vasodilation.

Supplementation Challenges:

Bioavailability: L-Arginine has lower bioavailability when taken orally due to rapid metabolism in the liver.

Gastrointestinal Distress: High doses of L-Arginine can cause gastrointestinal issues for some individuals.


L-Arginine has been studied for its potential benefits in improving blood flow, enhancing exercise performance, and supporting cardiovascular health.

L-Citrulline Malate:

Amino Acid Role: L-Citrulline is a non-essential amino acid that can be synthesized by the body. L-Citrulline Malate is a combination of L-Citrulline and malic acid.

Nitric Oxide Production: L-Citrulline is converted to L-Arginine in the kidneys, and this conversion leads to sustained nitric oxide production. Malic acid can contribute to improved cellular energy production.

Improved Bioavailability:

Stability: L-Citrulline has better stability and bioavailability compared to L-Arginine.

Reduced Gastrointestinal Distress: L-Citrulline is often preferred over L-Arginine for individuals sensitive to gastrointestinal side effects.


L-Citrulline Malate is commonly used as a supplement to enhance exercise performance, reduce muscle soreness, and support cardiovascular health.


Conversion to Nitric Oxide: L-Citrulline is more efficiently converted to L-Arginine in the body compared to direct L-Arginine supplementation, leading to more sustained nitric oxide production.

Dosage and Timing: L-Citrulline Malate is often preferred due to its better bioavailability and reduced side effects. It's typically taken in lower doses and may be more suitable for pre-workout supplementation.

Endurance and Recovery: L-Citrulline Malate has been specifically studied for its potential benefits in improving endurance, reducing muscle soreness, and promoting recovery after exercise.


Both L-Arginine and L-Citrulline Malate are involved in nitric oxide production and can have applications in supporting blood flow and exercise performance. However, due to the challenges associated with L-Arginine supplementation, many individuals prefer L-Citrulline Malate for its better bioavailability and reduced side effects. As with any supplement, individual responses can vary, and it's advisable to consult with a healthcare professional or a nutritionist before adding these supplements to your routine, especially if you have pre-existing health conditions.


Commenting has been turned off.
bottom of page